Hepatoprotective and Antioxidant Activities of Phenolic Compounds from <i>Heliciopsis terminalis</i>

Objective Heliciopsis terminalis (Kurz.) Sleum (family Proteaceae) is distributed in India, Mianma, Thailand, Cambodia, Vietnam, and China. In Vietnamese traditional medicine, it used as an antidote for detoxifying the liver alcohol, a contraceptive, to treat infections. The purpose of this study determine chemical constituents plant, well their vitro hepatoprotective antioxidant activities. Methods dried powdered sample was ultrasonically extracted with MeOH, extract fractionated by various chromatographic methods, including high-performance liquid chromatography. structures isolated compounds were identified NMR, high-resolution electrospray ionization mass spectrometry, CD spectral analysis, then screened Results One new phenolic glycoside, named helitermioside (1), eight known (2-9) from trunk branches H terminalis. All isolates reported first time. Compound 6 showed activity thiobarbituric acid reactive substances (TBARS) lipid peroxidation inhibition assays, IC 50 value 61.16 ± 1.17 µg/mL, compared that Trolox (positive control), = 7.06 0.11 µg/mL. At concentration 100 none exhibited hepatocellular protective activity. Conclusion Nine (1–9) recorded Of these, compound 1 new. moderate TBARS but against CCl 4 -induced toxicity.